TOPTOP > English > Custom Manufacturing Services > Ethical and OTC Drugs

Ethical and OTC DrugsFeatures of custom manufacturing services of ethical and OTC drugs of IWAKI SEIYAKU CO., LTD.

We can respond to any request for custom manufacturing,
from pharmaceutical design to production.

You may have any problems with pharmaceutical design and/or manufacturing of an ointment, cream, lotion, solution, etc.

We confidently provide custom manufacturing, from pharmaceutical design to production, based on long-term accumulated research on dermatological drugs and various dosage forms.
In particular, creams and lotions of emulsifying agents require various base, depending on the main ingredients.
Since the base is easily separated, we have established stabilization technology based on our long-term research on emulsifying drugs.

We can respond to requests for volume production or high-mix low-volume manufacturing.
In addition, we can also respond to requests for investigational new drug GMP.
Please consult us regarding matters outside examination of formulation designs and commercial scale production.


岩城製薬

Pharmaceutical technology

Technological development skills

Nonproprietary name Product name Ointment Cream Lotion
Difluprednate Stibron
Standard drug  
Clobetasone butyrate Paldes
Standard drug    
Dexamethasone Dexamethasone
Standard drug    

Pharmaceutical technology

Dermatological drugs Dosage form Technology Remarks
Ointment Dispersion Various dispersion methods will be selected based on the stability and efficacy (skin permeability) of ingredients.
Texture Varies significantly by viscosity and spread. The optimal sense of use can be performed.
Cream O/W type, W/O type base Creams are available in both types.
Lotion Base stability We established technology to select stable bases based on our long-term research on emulsifying agents.
Solution Dispersion Like for ointments, various dispersion methods will be selected based on stability and efficacy (skin permeability) of ingredients.
Sense of use Varies significantly by viscosity and spread. We aim to realize the optimal sense of use.
Internal drugs Tablets Internal drugs Antiallergic drugs, laxatives, frequent urination drugs, anxiolytics, vitamin drugs, synthetic antibacterials, and more.
Solutions Taste Antitussives
Troches Taste Mouth disinfectant
Syrup Taste Antitussives

Experiences of custom manufacturing services

Ointments Manufacturing methods and IND Production
Lotions Manufacturing methods and IND Production
Ointments
Examination for drug product formulation of creams containing new excipients Pharmaceutical formulation designs, standard test methods, stability tests
Examination for formulation of combined lotions (four active ingredients) Standard test methods, stability tests, comercial scale production
新規添加剤含有クリーム
Examination for formulation of combined ointments and creams (four active ingredients) Standard test methods, stability tests, comercial scale production
配合(有効成分4種)軟膏・クリーム

custom manufacturing services

custom manufacturing services
IWAKI SEIYAKU CO., LTD. has accumulated research on dermatological drugs and technologies related to various dosage forms over many years. We select the optimal base and manufacturing method in consideration of the characteristics, etc., of the ingredients.
We design pharmaceuticals in consideration of all possible concerns, including physical stability, appearance, sense of use, and efficacy of pharmaceutical products, as well as the chemical stability of the active ingredients.
Please feel free to contact us for production and research related to dermatological drugs.

Dosage forms available for custom manufacturing services

Dermatological drugs

Pharmaceutical formulation designs
Ointment (dissolution, dispersion)
Cream (O/W, W/O)
Lotion (O/W, W/O)
external solution
Gel
Sol
Investigational new drugs
Ointment (dissolution, dispersion)
Cream (O/W, W/O)
Lotion (O/W, W/O)
external solution
Gel
Sol
Commercial scale production
Ointment (dissolution, dispersion)
Cream (O/W, W/O)
Lotion (O/W, W/O)
external solution
Gel
Sol

Internal drugs

Pharmaceutical formulation designs
Oral solution
Powder
Tablets
OD tablets
Investigational new drugs
Oral solution
Powder
Tablets
OD tablets
Granules
Commercial scale production
Oral solution
Powder
Tablets
OD tablets

Test and Assessment

We implement tests and assessments for the following items:

  • Stability test (measurement: Temperature: -80°C to 60°C, light, humidity)
  • Preservative-effectiveness test
  • Viable count test
  • Absorption performance test (permeability, release)
  • Physical properties evaluation (viscosity, spreadability, consistency, speculum)

Introduction to our facilities

Kamata Plant

Main facilities

  • Lotion filling machine
    Lotion filling machine
  • Cutting-edge filling machine for PTP packaging of tablets

    Cutting-edge filling machine for PTP packaging of tablets

  Process Facilities
Solid preparations Granulation Mixing and granulating machine
Granulate-refining Crushing-type sizer
Drying Chamber dryer
Mixing V-shape mixer
Tableting Tableting machine
Film coating Vented tablet coating machine
Inspection Tablet checker
Filling and packaging Powder filling line
PTP filling and pillow-type packaging line
Solutions and semi-solid preparations

Preparation

Dissolution tank

Storage tank
Vacuum emulsifier

Filling and packaging

Lotion filling machine
Tube filling line
Tack labeling machine
Cartoning line
Shrink-packaging line

Flow of Custom Manufacturing Services

The person responsible for examination of Pharmaceutical formulation designs will handle manufacturing of investigational new drug products, trial manufacturing, etc., establish safe and sure Pharmaceutical formulation designs, and start manufacturing.

岩城製薬受フロー図